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Learn more about the terpene, Nerolidol on our blog post this week!

Although it can be automatic to assume that the THC percentages and potency in each strain are the only driving force behind the effectiveness of the cannabis derived medicine, it is actually the aromatic essential oils, the terpenes, that truly have the greatest effect. Terpenes can help to enhance the cannabis plant by acting as specific guides for navigating through the individual strain effecting an individual, acting as catalysts for the cannabis effectiveness. While the purpose of terpenes is geared towards the natural process of prohibiting and inhibiting predators on plant leaves, analyzing the terpenes found in high amounts within a strain help to show how the plant might affect a person in different ways, depending on the kind of terpene found.

One of the terpenes found in some strains is Nerolidol. Nerolidol is a sesquiterpene, meaning it has three isoprene units with five Carbon atoms in each unit. In one study, such sesquiterpenes were said to be defenses against pathogens, interactions with pollinators, and connected with environmental acclimations to stress. (Weiguo, 2021)

Similar to other terpenes, Nerolidol can be found in many plants in addition to just cannabis, such as tea tree, jasmine, neroli, lemon grass, and lavender.

In one study, it was discovered that nerolidol can possibly help with the anxiety and pain management levels produced during childbirth, making it potentially effective to use to combat nerves and pain. (Scandurra, 2022) Further, with its relationship regarding neroli which is found in bitter orange blossoms, Nerolidol can possibly have citrus, apple, floral, and rose aromas or notes.

This interconnectedness also showcases the properties Nerolidol has in terms of possible benefits. Potential benefits can include sedation, anti-anxiety, anti-fungal, and antioxidant abilities of the terpene. As it is found in citrus and other sources of natural variety, the Food and Drug Administration has also approved Nerolidol use as a food additive, perfume, and cleanser. According to one study, Nerolidol can also be used in insect repellants, sometimes warding off potential bugs due to the strength of its antioxidant and anti-bacterial powers. When utilized in conjunction with antibiotics, Nerolidol can provide more effectiveness for patients by battling pathogens entering the bodies system. Additionally, it can be used topically and possibly provide skin irritation relief and potentially help other medications absorb more efficiently.

Overall, Nerolidol can possibly be utilized as an effective tool for mitigating anxiety while helping aid in sedative relief and provide other benefits. Although more studies need to be completed regarding this terpene, it remains to be an important component of cannabis plants and their medicinal abilities. Always consult with a physician before beginning any new regime.


Weiguo, Li. “Characterization of Trans-Nerolidol Synthase from Celastrus Angulatus Maxim and Production of Trans-Nerolidol in Engineered Saccharomyces Cerevisiae.” 2021,

Scandurra, Cristiano, et al. “The Effectiveness of Neroli Essential Oil in Relieving Anxiety and Perceived Pain in Women during Labor: A Randomized Controlled Trial.” Healthcare, vol. 10, no. 2, 2022, p. 366.,

ŠPIČÁKOVÁ, A., et al. “Β‐Caryophyllene Oxide and Trans-Nerolidol Affect Enzyme Activity of CYP3A4 – in Vitro and in Silico Studies.” Physiological Research, 2019,

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